Experimental osteonecrosis: development of a model in rodents administered alendronate

• Main Authors: Nicolau CONTE NETO (Author), Luis Carlos SPOLIDORIO (Author), Cleverton Roberto de ANDRADE (Author), Jônatas Caldeira ESTEVES (Author), Elcio MARCANTONIO JR (Author)
• Format: Book
• Published: Sociedade Brasileira de Pesquisa Odontológica.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The main objective of this study was to cause bisphosphonate-related osteonecrosis of the jaws to develop in a rodent model. Adult male Holtzman rats were assigned to one of two experimental groups to receive alendronate (AL; 1 mg/kg/week; n = 6) or saline solution (CTL; n = 6). After 60 da...