An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag <subtitle>Short title: Controlled bioconjugation via O-glycan engineering</subtitle>

• Main Authors: Thomas V. Murray (Author), Kasia Kozakowska-McDonnell (Author), Adam Tibbles (Author), Annabel Taylor (Author), Daniel Higazi (Author), Emmanuel Rossy (Author), Alessandra Rossi (Author), Sivaneswary Genapathy (Author), Giulia Tamburrino (Author), Nicola Rath (Author), Natalie Tigue (Author), Vivian Lindo (Author), Tristan Vaughan (Author), Monika A. Papworth (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bioconjugates are an important class of therapeutic molecules. To date, O-glycan-based metabolic glycoengineering has had limited use in this field, due to the complexities of the endogenous O-glycosylation pathway and the lack of an O-glycosylation consensus sequence. Here, we describe the developm...