Preparation and evaluation of poly(l-histidine) based pH-sensitive micelles for intracellular delivery of doxorubicin against MCF-7/ADR cells

• Główni autorzy: Nan Jia (Autor), Yuqing Ye (Autor), Qi Wang (Autor), Xiuli Zhao (Autor), Haiyang Hu (Autor), Dawei Chen (Autor), Mingxi Qiao (Autor)
• Format: Książka
• Wydane: Elsevier, 2017-09-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

In this study, a pH-sensitive micelle self-assembled from poly(l-histidine) based triblock copolymers of poly(ethylene glycol)-poly(d,l-lactide)-poly(l-histidine) (mPEG-PLA-PHis) was prepared and used as the intracellular doxorubicin (Dox) delivery for cancer chemotherapy. Dox was loaded into the mi...