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Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

The haem enzyme indoleamine 2,3-dioxygenase 1 (IDO1) catalyses the rate-limiting step in the kynurenine pathway of tryptophan metabolism and plays an essential role in immunity, neuronal function, and ageing. Expression of IDO1 in cancer cells results in the suppression of an immune response, and th...

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Main Authors: Ute F. Röhrig (Author), Somi Reddy Majjigapu (Author), Pierre Vogel (Author), Aline Reynaud (Author), Florence Pojer (Author), Nahzli Dilek (Author), Patrick Reichenbach (Author), Kelly Ascenção (Author), Melita Irving (Author), George Coukos (Author), Olivier Michielin (Author), Vincent Zoete (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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