Induction of allopurinol resistance in Leishmania infantum isolated from dogs.

• Main Authors: Daniel Yasur-Landau (Author), Charles L Jaffe (Author), Adi Doron-Faigenboim (Author), Lior David (Author), Gad Baneth (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Resistance to allopurinol in zoonotic canine leishmaniasis has been recently shown to be associated with disease relapse in naturally-infected dogs. However, information regarding the formation of resistance and its dynamics is lacking. This study describes the successful in-vitro induction of allop...