Stir bar-sorptive extraction, solid phase extraction and liquid-liquid extraction for levetiracetam determination in human plasma: comparing recovery rates

• Main Authors: Priscila Freitas-Lima (Author), Flavia Isaura Santi Ferreira (Author), Carlo Bertucci (Author), Veriano Alexandre Júnior (Author), Sônia Aparecida Carvalho Dreossi (Author), Leonardo Regis Leira Pereira (Author), Américo Ceiki Sakamoto (Author), Regina Helena Costa Queiroz (Author)
• Format: Book
• Published: Universidade de São Paulo, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Levetiracetam (LEV), an antiepileptic drug (AED) with favorable pharmacokinetic profile, is increasingly being used in clinical practice, although information on its metabolism and disposition are still being generated. Therefore a simple, robust and fast liquid-liquid extraction (LLE) foll...