Role of tubular cell-derived exosomes in renal ischemia reperfusion injury

Renal ischemia reperfusion injury refers to a pathophysiological phenomenon that aggravates the degree of renal injury due to the restoration of blood supply after transient ischemia of renal tissue. It has been found that renal tubular cell-derived exosomes alleviate renal ischemia reperfusion inju...

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Main Authors: Jin-zhu Huang (Author), Yan-zi Zhang (Author), Cui-yu Yang (Author), Ai-sha Zhang (Author), Xiao-lu Sui (Author), Yun-peng Xu (Author), Ting-fei Xie (Author), Ji-hong Chen (Author)
Format: Book
Published: Editorial Department of Journal of Clinical Nephrology, 2024-11-01T00:00:00Z.
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Summary:Renal ischemia reperfusion injury refers to a pathophysiological phenomenon that aggravates the degree of renal injury due to the restoration of blood supply after transient ischemia of renal tissue. It has been found that renal tubular cell-derived exosomes alleviate renal ischemia reperfusion injury through anti-inflammatory, antioxidant, inhibition of apoptosis, promotion of tissue regeneration and activation of autophagy . This review will discuss the protective effect of tubular cell-derived exosomes on renal ischemia reperfusion injury, in order to provide a theoretical basis for the clinical diagnosis, treatment and early prevention of renal ischemia reperfusion injury.
Item Description:1671-2390
10.3969/j.issn.1671-2390.2024.11.009