Synthesis and cytotoxic evaluation of some new 3-(2-(2-phenylthiazol-4-yl) ethyl)-quinazolin-4(3H) one derivatives with potential anticancer effects
Quinazolinones are a group of heterocyclic compounds that have important biological activities such as cytotoxicity, anti-bacterial, and anti-fungal effects. Thiazole-containing compounds have also many biological effects including antitumor, antibacterial, anti-inflammatory, and analgesic activitie...
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| Principais autores: | , , , , |
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| Formato: | Livro |
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Wolters Kluwer Medknow Publications,
2017-01-01T00:00:00Z.
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| Resumo: | Quinazolinones are a group of heterocyclic compounds that have important biological activities such as cytotoxicity, anti-bacterial, and anti-fungal effects. Thiazole-containing compounds have also many biological effects including antitumor, antibacterial, anti-inflammatory, and analgesic activities. Due to significant cytotoxic effects of both quinazoline and thiazole derivatives, in this work a group of quinazolinone-thiazol hybrids were prepared and their cytotoxic effects on three cell lines were evaluated using MTT assay. Compounds A3, A2 , B4 , and A1 showed highest cytotoxic activities against PC3 cell line. Compounds A3 , A5 , and A2 were most active against MCF-7 and A3 , A5 , and A6 showed good cytotoxic effect on HT-29 cell line. According to the results, A3 efficiently inhibited all cell growth tested in a dose dependent manner. The IC 50 of A3 was 10 M, 10 μM, and 12 μM on PC3, MCF-7, and HT-29 cells, respectively. |
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| Descrição do item: | 1735-5362 1735-9414 10.4103/1735-5362.212046 |