Prevalence of Toxoplasma gondii Antibodies and DNA in Iranian HIV Patients

Background & Objective: Toxoplasma gondii infection has public health importance and can lead to serious diseases in immunosuppressed patients, such as HIV cases. Appropriate control of T. gondii infection in HIV patients requires information about the prevalence of T. gondii antibodies and DNA...

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Main Authors: Anahita Bavand (Author), Arezoo Aghakhani (Author), Minoo Mohraz (Author), Mohammad Banifazl (Author), Afsaneh Karami (Author), Majid Golkar (Author), Jalal Babaie (Author), Parviz Saleh (Author), Setareh Mamishi (Author), Amitis Ramezani (Author)
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Published: Iranian Society of Pathology, 2019-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Anahita Bavand  |e author 
700 1 0 |a Arezoo Aghakhani  |e author 
700 1 0 |a Minoo Mohraz  |e author 
700 1 0 |a Mohammad Banifazl  |e author 
700 1 0 |a Afsaneh Karami  |e author 
700 1 0 |a Majid Golkar  |e author 
700 1 0 |a Jalal Babaie  |e author 
700 1 0 |a Parviz Saleh  |e author 
700 1 0 |a Setareh Mamishi  |e author 
700 1 0 |a Amitis Ramezani  |e author 
245 0 0 |a Prevalence of Toxoplasma gondii Antibodies and DNA in Iranian HIV Patients 
260 |b Iranian Society of Pathology,   |c 2019-01-01T00:00:00Z. 
500 |a 1735-5303 
500 |a 2345-3656 
500 |a 10.30699/ijp.14.1.68 
520 |a Background & Objective: Toxoplasma gondii infection has public health importance and can lead to serious diseases in immunosuppressed patients, such as HIV cases. Appropriate control of T. gondii infection in HIV patients requires information about the prevalence of T. gondii antibodies and DNA in different population. In this study, we aimed to determine the prevalence of Toxoplasma gondii antibodies and DNA in HIV patients in Tehran, Iran.Methods: A total of 149 HIV patients from the Iranian Research Center for HIV/AIDS, Tehran, Iran were enrolled in the study. Anti-Toxoplasma IgG and IgM were detected by ELISA and T. gondii DNA was evaluated by PCR and quantitative real-time PCR. IgG positive samples were also assessed for their avidity. Results: Anti-Toxoplasma IgG and IgM were positive in 46.3% and 2.7% of cases respectively. 92.7% of our patients showed past infection and 4.3% revealed recently acquired toxoplasmosis based on their IgG avidity test. T. gondii DNA was not detected by PCR but real-time PCR results showed DNA in 4.7% of total patients and 13.1% of the IgG seropositive cases.Conclusion: Our findings indicated that latent toxoplasmosis was relatively prevalent in our study population, but new T. gondii infection had low prevalence. Almost half of our patients were IgG negative and at risk of acquiring toxoplasma infection. Low copy numbers of DNA were detected in 4.7% of the cases without any clinical manifestation. Therefore, detection and monitoring of anti-Toxoplasma antibodies and DNA in HIV patients is substantial to estimate the risk of reactivation and new infection. 
546 |a EN 
690 |a human immunodeficiency virus (hiv) 
690 |a igg 
690 |a igm 
690 |a toxoplasma gondii 
690 |a reactive inhibition antibodies 
690 |a Pathology 
690 |a RB1-214 
655 7 |a article  |2 local 
786 0 |n Iranian Journal of Pathology, Vol 14, Iss 1, Pp 68-75 (2019) 
787 0 |n https://ijp.iranpath.org/article_33642_94a16fb885cf80cbc12d37ec05784b86.pdf 
787 0 |n https://doaj.org/toc/1735-5303 
787 0 |n https://doaj.org/toc/2345-3656 
856 4 1 |u https://doaj.org/article/cfdcdde7197842a39f2bc7f59c3055f6  |z Connect to this object online.