Expression Toll-like receptors in the oral mucosa of patients with recurrent aphthous stomatitis
<span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>Toll-like receptors (TLRs) have recently emerged as key receptors of the innate immune system. They recognize specific pathogenassociated molecular patterns...
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| Format: | Book |
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Universitas Airlangga,
2008-03-01T00:00:00Z.
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| Summary: | <span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>Toll-like receptors (TLRs) have recently emerged as key receptors of the innate immune system. They recognize specific pathogenassociated molecular patterns initiating a host defence response. The oral mucosa epithelium encounters potential pathogens like </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>bacteria and viruses in inspired air, and the discovery of TLRs on epithelial cells suggest that the epithelium has a role in the mucosal </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>immune system. The aim of this study was to discover Recurrent Apthous Stomatitis (RAS) using etiopathogenetic molecular approach </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>by observing the TLRs. Immunohistochemistry using monoclonal antibodies anti-TLR-2, TLR-3, TLR-4, TLR-5, TLR-7 and TLR-9 were </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>used in this study. These antibodies are specific toward TLR on the surface of epithelial cells membrane and macrophages in patients </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>with major and minor RAS. TLR was expressed on the surface of epithelial cells membrane of oral mucosa and macrophages in both </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>major and minor RAS patients. TLRs was not expressed specifically in non-RAS patients. The results above showed indication, that </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>functional TLRs expression by epithelial cells in oral mucosa had remarkable implication on natural immune response and disease </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>pathogenesis. The expression of TLR was found in the oral mucous membrane on epithelial cells surface and macrophages patients </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>with RAS.</em></span></span></span></span></span></span></span></span></span><br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" /></span> |
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| Item Description: | 1978-3728 2442-9740 10.20473/j.djmkg.v41.i1.p47-51 |