Prevalence of Herpes Simplex Virus Type 1 and 2 (HSV-1 and HSV-2) in the Women with Breast Cancer by Multiplex-PCR method

• Main Authors: Fatemeh Kaveh (Author), Kumarss Amini (Author), Mojtaba Sadeh (Author)
• Format: Book
• Published: Mashhad University of Medical Sciences, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1680-2993; 2008-2363; 10.22038/ijogi.2018.11070
• Keywords: breast cancer; herpes simplex virus; multiplex-pcr; Gynecology and obstetrics; RG1-991
• Source: Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, Vol 21, Iss 3, Pp 39-44 (2018)

Introduction: Breast cancer is a common malignancy and a major cause of death in women. Viruses are considered as one of the risk factors associated with breast cancer. Herpes simplex virus-1 (HSV-1) and HSV-2 are involved in the pathogenesis of cancer. The present study was conducted to determine the frequency of HSV-1 and HSV-2 in the blood samples of patients with breast cancer using multiplex-polymerase chain reaction (M-PCR) technique. methods: This cross-sectional study was conducted on 60 breast cancer patients within 2014-2015. The infection with HSV-1 and HSV-2 was investigated by M-PCR. All data were analyzed using SPSS software (version 18). Results: Out of the 60 blood samples obtained from patients with breast cancer, 6 (10%) and 3 (5%) samples were positive for HSV-1 and HSV-2, respectively. Conclusion: herpes simplex virus, especially HSV-1, can play a role as a cofactor in the incidence of breast cancer, so further studies are recommended in this area.