Stability Study of Parenteral N-Acetylcysteine, and Chemical Inhibition of Its Dimerization

• Main Authors: Nicolas Primas (Author), Guillaume Lano (Author), Damien Brun (Author), Christophe Curti (Author), Marion Sallée (Author), Emmanuelle Sampol-Manos (Author), Edouard Lamy (Author), Charleric Bornet (Author), Stéphane Burtey (Author), Patrice Vanelle (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parenteral N-acetylcysteine has a wide variety of clinical applications, but its use can be limited by a poor chemical stability. We managed to control parenteral N-acetylcysteine stability, and to study the influence of additives on the decrease of N-acetylcysteine degradation. First, an HPLC-UV do...