Cover Image

Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells

As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management. To identify a specific inhibitor of TrkA activity, we designed cell-penetrating peptides combined...

Full description

Saved in:

Bibliographic Details
Main Authors:	Munetaka Hirose (Author), Mayumi Takatori (Author), Yoshihiro Kuroda (Author), Mineo Abe (Author), Eri Murata (Author), Tetsuro Isada (Author), Koyo Ueda (Author), Kenji Shigemi (Author), Masayuki Shibazaki (Author), Fumihiro Shimizu (Author), Masashi Hirata (Author), Keita Fukazawa (Author), Masahiro Sakaguchi (Author), Kyoko Kageyama (Author), Yoshifumi Tanaka (Author)
Format:	Book
Published:	Elsevier, 2008-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Neuropathic Pain in Mice
by: Wei-Ying Ma, et al.
Published: (2010)

Local Administration of a Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Inflammatory Pain in Rats
by: Koyo Ueda, et al.
Published: (2010)

Role of NGF/TrkA signaling milieu in depressogenic induction of rat brain
by: Ritabrata Banerjee, et al.
Published: (2013)

Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner
by: Tongtong Sui, et al.
Published: (2021)

IMMUNOHISTOCHEMICAL EXPRESSION OF NGF/TrkA AND BDNF/TrkB IN TUMOR PARIENCHYMA AND PERIPROSTATIC ADIPOSE TISSUE, DEPENDING ON THE PATHOANATOMIC STAGE OF PROSTATE CANCER
by: Nikolay Evtimov
Published: (2024)

Research of neuroprotective properties of TrkA-receptor agonist GK-2 on model of oxidative stress in human vascular endothelial cells (HUVEC)
by: T. A. Antipova, et al.
Published: (2019)

Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways
by: Wang T, et al.
Published: (2020)

Endothelial TrkA coordinates vascularization and innervation in thermogenic adipose tissue and can be targeted to control metabolism
by: Alexes C. Daquinag, et al.
Published: (2022)

Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway
by: Xu Gao, et al.
Published: (2021)

How Tongxie-Yaofang Regulates Intestinal Synaptic Plasticity by Activating Enteric Glial Cells and NGF/TrkA Pathway in Diarrhea-Predominant Irritable Bowel Syndrome Rats
by: Lu X, et al.
Published: (2023)

Low levels of the nerve growth factor receptor TrkA in JIA: a possible defect in a novel anti-inflammatory mechanism
by: Bracci-Laudiero L, et al.
Published: (2011)

Low levels of the nerve growth factor receptor TrkA in JIA: a possible defect in a novel anti-inflammatory mechanism
by: Bracci-Laudiero L, et al.
Published: (2011)

Suppression of CGRP and TRPV1 Expression in Dorsal Root Ganglia of Knee Osteoarthritis Rats by Huojing Decoction via TrkA/MKK3/6/p38 Pathway
by: Jiang X, et al.
Published: (2024)

Electroacupuncture at ST36 Relieves Visceral Hypersensitivity via the NGF/TrkA/TRPV1 Peripheral Afferent Pathway in a Rodent Model of Post-Inflammation Rectal Hypersensitivity
by: Chen Y, et al.
Published: (2021)

Electroacupuncture at ST36 Relieves Visceral Hypersensitivity via the NGF/TrkA/TRPV1 Peripheral Afferent Pathway in a Rodent Model of Post-Inflammation Rectal Hypersensitivity [Erratum]
by: Chen Y, et al.
Published: (2021)

α-Mangostin Induces Ca2+-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells
by: Ayumi Sato, et al.
Published: (2004)

Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists
by: Piotr Pankiewicz, et al.
Published: (2021)

Rational design and crystallographic analysis of novel isoform-selective TRKA inhibitors for cancer therapy
by: Guan Wang, et al.
Published: (2023)

Downregulation of TrkC Receptors Increases Dendritic Arborization of Purkinje Cells in the Developing Cerebellum of the Opossum, Monodelphis domestica
by: Beata Tepper, et al.
Published: (2020)

The effects of hesperetin on apoptosis induction and inhibition of cell proliferation in the prostate cancer PC3 cells
by: Shirzad Moein, et al.
Published: (2015)

Neuroprotective effect of (R)-(-)-linalool on oxidative stress in PC12 cells
by: Rossana Migheli, et al.
Published: (2021)

Antiischemic properties of the Trka-receptor agonist, the nerve growth factor 4-th loop mimetic
by: E. S. Pekeldina, et al.
Published: (2018)

PC
Published: (2014)

Honeybee Royal Jelly and Nobiletin Stimulate CRE-Mediated Transcription in ERK-Independent and -Dependent Fashions, Respectively, in PC12D Cells
by: Hironori Fujiwara, et al.
Published: (2011)

Corrigendum: Downregulation of TrkC Receptors Increases Dendritic Arborization of Purkinje Cells in the Developing Cerebellum of the Opossum, Monodelphis domestica
by: Beata Tepper, et al.
Published: (2020)

Low Doses of Camptothecin Induced Hormetic and Neuroprotective Effects in PC12 Cells
by: Chao Zhang, et al.
Published: (2015)

Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells
by: Aya Yamamura, et al.
Published: (2019)

The protective effect of sodium benzoate on aluminum toxicity in PC12 cell line
by: Rita Arabsolghar, et al.
Published: (2017)

Icariin promotes the repair of PC12 cells by inhibiting endoplasmic reticulum stress
by: Chengjie Wu, et al.
Published: (2021)

Norwogonin attenuates hypoxia-induced oxidative stress and apoptosis in PC12 cells
by: Linlin Jing, et al.
Published: (2021)

Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation
by: Norikazu Kiguchi, et al.
Published: (2017)

Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma
by: Pacenta HL, et al.
Published: (2018)

TRK Inhibitors: Tissue-Agnostic Anti-Cancer Drugs
by: Sun-Young Han
Published: (2021)

Inhibition of human prostate cancer (PC-3) cells and targeting of PC-3-derived prostate cancer stem cells with koenimbin, a natural dietary compound from Murraya koenigii (L) Spreng
by: Kamalidehghan B, et al.
Published: (2018)

Donepezil Potentiates Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells
by: Toru Oda, et al.
Published: (2007)

Lafutidine-Induced Increase in Intracellular Ca2+ Concentrations in PC12 and Endothelial Cells
by: Kana Kunieda, et al.
Published: (2005)

Study of High Glucose-Induced Apoptosis in PC12 Cells: Role of Bax Protein
by: Ali M. Sharifi, et al.
Published: (2007)

Effect of Adenosine Receptor Antagonists on Adenosine-Pretreated PC12 Cells Exposed to Paraquat
by: Liangcheng Shang, et al.
Published: (2022)

Light-Triggerable Liposomes for Enhanced Endolysosomal Escape and Gene Silencing in PC12 Cells
by: Wenjie Chen, et al.
Published: (2017)

Inhibition of Autophagy Enhances Sunitinib-Induced Cytotoxicity in Rat Pheochromocytoma PC12 cells
by: Tatsuhiko Ikeda, et al.
Published: (2013)