Iron Oxide Nanoparticles in Cancer Treatment: Cell Responses and the Potency to Improve Radiosensitivity

• मुख्य लेखकों: Maria V. Shestovskaya (लेखक), Anna L. Luss (लेखक), Olga A. Bezborodova (लेखक), Valentin V. Makarov (लेखक), Anton A. Keskinov (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.
• Notes: 10.3390/pharmaceutics15102406; 1999-4923
• Keywords: radiosensitization; iron oxide nanoparticles; iron reactivity; cancer treatment; ionizing radiation; Pharmacy and materia medica; RS1-441
• Source: Pharmaceutics, Vol 15, Iss 10, p 2406 (2023)

The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads to an increase in the potency of radiation therapy and allows for decreasing radiation dose and the concomitant side effects. Radiosensitization by metal oxide nanoparticles is widely discussed, but the range of mechanisms studied is not sufficiently codified and often does not reflect the ability of nanocarriers to have a specific impact on cells. This review is focused on the magnetic iron oxide nanoparticles while they occupied a special niche among the prospective radiosensitizers due to unique physicochemical characteristics and reactivity. We collected data about the possible molecular mechanisms underlying the radiosensitizing effects of iron oxide nanoparticles (IONPs) and the main approaches to increase their therapeutic efficacy by variable modifications.