Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder

• Main Authors: Bidisha Rajkhowa (Author), Sidharth Mehan (Author), Pranshul Sethi (Author), Aradhana Prajapati (Author), Manisha Suri (Author), Sumit Kumar (Author), Sonalika Bhalla (Author), Acharan S. Narula (Author), Abdulrahman Alshammari (Author), Metab Alharbi (Author), Nora Alkahtani (Author), Saeed Alghamdi (Author), Reni Kalfin (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bipolar disorder (BD) is a chronic mental illness characterized by mood fluctuations that range from depressive lows to manic highs. Several studies have linked the downregulation of SIRT-1 (silent mating type information regulation-2 homologs) signaling to the onset of BD and other neurological dys...