A novel drug-like water-soluble small molecule Focal Adhesion Kinase (FAK) activator promotes intestinal mucosal healing

• Main Authors: Qinggang Wang (Author), Ricardo Gallardo-Macias (Author), Emilie E. Vomhof-DeKrey (Author), Rashmi Gupta (Author), Svetlana A. Golovko (Author), Mikhail Y. Golovko (Author), Sema Oncel (Author), Vadim J. Gurvich (Author), Marc D. Basson (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Non-steroidal anti-inflammatory drugs (NSAIDs) injure the proximal and distal gut by different mechanisms. While many drugs reduce gastrointestinal injury, no drug directly stimulates mucosal wound healing. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, induces epithelial sheet migrati...