Epigenetic Alterations and an Increased Frequency of Micronuclei in Women with Fibromyalgia

Fibromyalgia (FM), characterized by chronic widespread pain, fatigue, and cognitive/mood disturbances, leads to reduced workplace productivity and increased healthcare expenses. To determine if acquired epigenetic/genetic changes are associated with FM, we compared the frequency of spontaneously occ...

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Main Authors: Victoria Menzies (Author), Debra E. Lyon (Author), Kellie J. Archer (Author), Qing Zhou (Author), Jenni Brumelle (Author), Kimberly H. Jones (Author), G. Gao (Author), Timothy P. York (Author), Colleen Jackson-Cook (Author)
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Published: Hindawi Limited, 2013-01-01T00:00:00Z.
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100 1 0 |a Victoria Menzies  |e author 
700 1 0 |a Debra E. Lyon  |e author 
700 1 0 |a Kellie J. Archer  |e author 
700 1 0 |a Qing Zhou  |e author 
700 1 0 |a Jenni Brumelle  |e author 
700 1 0 |a Kimberly H. Jones  |e author 
700 1 0 |a G. Gao  |e author 
700 1 0 |a Timothy P. York  |e author 
700 1 0 |a Colleen Jackson-Cook  |e author 
245 0 0 |a Epigenetic Alterations and an Increased Frequency of Micronuclei in Women with Fibromyalgia 
260 |b Hindawi Limited,   |c 2013-01-01T00:00:00Z. 
500 |a 2090-1429 
500 |a 2090-1437 
500 |a 10.1155/2013/795784 
520 |a Fibromyalgia (FM), characterized by chronic widespread pain, fatigue, and cognitive/mood disturbances, leads to reduced workplace productivity and increased healthcare expenses. To determine if acquired epigenetic/genetic changes are associated with FM, we compared the frequency of spontaneously occurring micronuclei (MN) and genome-wide methylation patterns in women with FM (n=10) to those seen in comparably aged healthy controls (n=42 (MN); n=8 (methylation)). The mean (sd) MN frequency of women with FM (51.4 (21.9)) was significantly higher than that of controls (15.8 (8.5)) (χ2=45.552; df = 1; P=1.49×10-11). Significant differences (n=69 sites) in methylation patterns were observed between cases and controls considering a 5% false discovery rate. The majority of differentially methylated (DM) sites (91%) were attributable to increased values in the women with FM. The DM sites included significant biological clusters involved in neuron differentiation/nervous system development, skeletal/organ system development, and chromatin compaction. Genes associated with DM sites whose function has particular relevance to FM included BDNF, NAT15, HDAC4, PRKCA, RTN1, and PRKG1. Results support the need for future research to further examine the potential role of epigenetic and acquired chromosomal alterations as a possible biological mechanism underlying FM. 
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787 0 |n https://doaj.org/toc/2090-1429 
787 0 |n https://doaj.org/toc/2090-1437 
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