Secreted Factors from Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury

Acute kidney injury is a devastating syndrome that afflicts over 2,000,000 people in the US per year, with an associated mortality of greater than 70% in severe cases. Unfortunately, standard-of-care treatments are not sufficient for modifying the course of disease. Many groups have explored the use...

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Main Authors: Jack M. Milwid (Author), Takaharu Ichimura (Author), Matthew Li (Author), Yunxin Jiao (Author), Jungwoo Lee (Author), Joshua S. Yarmush (Author), Biju Parekkadan (Author), Arno W. Tilles (Author), Joseph V. Bonventre (Author), Martin L. Yarmush (Author)
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Published: Hindawi Limited, 2012-01-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Jack M. Milwid  |e author 
700 1 0 |a Takaharu Ichimura  |e author 
700 1 0 |a Matthew Li  |e author 
700 1 0 |a Yunxin Jiao  |e author 
700 1 0 |a Jungwoo Lee  |e author 
700 1 0 |a Joshua S. Yarmush  |e author 
700 1 0 |a Biju Parekkadan  |e author 
700 1 0 |a Arno W. Tilles  |e author 
700 1 0 |a Joseph V. Bonventre  |e author 
700 1 0 |a Martin L. Yarmush  |e author 
245 0 0 |a Secreted Factors from Bone Marrow Stromal Cells Upregulate IL-10 and Reverse Acute Kidney Injury 
260 |b Hindawi Limited,   |c 2012-01-01T00:00:00Z. 
500 |a 1687-966X 
500 |a 1687-9678 
500 |a 10.1155/2012/392050 
520 |a Acute kidney injury is a devastating syndrome that afflicts over 2,000,000 people in the US per year, with an associated mortality of greater than 70% in severe cases. Unfortunately, standard-of-care treatments are not sufficient for modifying the course of disease. Many groups have explored the use of bone marrow stromal cells (BMSCs) for the treatment of AKI because BMSCs have been shown to possess unique anti-inflammatory, cytoprotective, and regenerative properties in vitro and in vivo. It is yet unresolved whether the primary mechanisms controlling BMSC therapy in AKI depend on direct cell infusion, or whether BMSC-secreted factors alone are sufficient for mitigating the injury. Here we show that BMSC-secreted factors are capable of providing a survival benefit to rats subjected to cisplatin-induced AKI. We observed that when BMSC-conditioned medium (BMSC-CM) is administered intravenously, it prevents tubular apoptosis and necrosis and ameliorates AKI. In addition, we observed that BMSC-CM causes IL-10 upregulation in treated animals, which is important to animal survival and protection of the kidney. In all, these results demonstrate that BMSC-secreted factors are capable of providing support without cell transplantation, and the IL-10 increase seen in BMSC-CM-treated animals correlates with attenuation of severe AKI. 
546 |a EN 
690 |a Internal medicine 
690 |a RC31-1245 
655 7 |a article  |2 local 
786 0 |n Stem Cells International, Vol 2012 (2012) 
787 0 |n http://dx.doi.org/10.1155/2012/392050 
787 0 |n https://doaj.org/toc/1687-966X 
787 0 |n https://doaj.org/toc/1687-9678 
856 4 1 |u https://doaj.org/article/d12e6a5fc8d849d3ad2965f2016f1535  |z Connect to this object online.