Population Pharmacokinetics Modelling and Simulation of Mitotane in Patients with Adrenocortical Carcinoma: An Individualized Dose Regimen to Target All Patients at Three Months?
Mitotane is the most effective agent in post-operative treatment of adrenocortical carcinoma. In adults, the starting dose is 2−3 g/day and should be slightly increased to reach the therapeutic index of 14−20 mg/L. This study developed a population PK model for mitotane and to simulate recommended/h...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2019-10-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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