Population Pharmacokinetics Modelling and Simulation of Mitotane in Patients with Adrenocortical Carcinoma: An Individualized Dose Regimen to Target All Patients at Three Months?

• Main Authors: Yoann Cazaubon (Author), Yohann Talineau (Author), Catherine Feliu (Author), Céline Konecki (Author), Jennifer Russello (Author), Olivier Mathieu (Author), Zoubir Djerada (Author)
• Format: Book
• Published: MDPI AG, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitotane is the most effective agent in post-operative treatment of adrenocortical carcinoma. In adults, the starting dose is 2−3 g/day and should be slightly increased to reach the therapeutic index of 14−20 mg/L. This study developed a population PK model for mitotane and to simulate recommended/h...