Upregulation of lncRNA NR_046683 Serves as a Prognostic Biomarker and Potential Drug Target for Multiple Myeloma
Aim: To investigate the prognostic value of lncRNA NR_046683 in multiple myeloma (MM).Methods: High-throughput lncRNA array was combined with bioinformatics techniques to screen differentially expressed lncRNA in MM. qRT-PCR was adopted to determine the expression of target lncRNAs in MM patients an...
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| Format: | Book |
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Frontiers Media S.A.,
2019-01-01T00:00:00Z.
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MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_d1900d1467ce4bbda3d24b43f1fcfceb | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Hang Dong |e author |
| 700 | 1 | 0 | |a Siyi Jiang |e author |
| 700 | 1 | 0 | |a Yunfeng Fu |e author |
| 700 | 1 | 0 | |a Yanwei Luo |e author |
| 700 | 1 | 0 | |a Rong Gui |e author |
| 700 | 1 | 0 | |a Jing Liu |e author |
| 245 | 0 | 0 | |a Upregulation of lncRNA NR_046683 Serves as a Prognostic Biomarker and Potential Drug Target for Multiple Myeloma |
| 260 | |b Frontiers Media S.A., |c 2019-01-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2019.00045 | ||
| 520 | |a Aim: To investigate the prognostic value of lncRNA NR_046683 in multiple myeloma (MM).Methods: High-throughput lncRNA array was combined with bioinformatics techniques to screen differentially expressed lncRNA in MM. qRT-PCR was adopted to determine the expression of target lncRNAs in MM patients and controls.Results: It was found for the first time that lncRNA NR_046683 is closely related to the prognosis of MM. It was also detected in tumor cell lines KM3, U266, especially in drug-resistant cell lines KM3/BTZ and MM1R. The NR_046683 expression differed significantly in patients of different MM subtypes and staging. Moreover, the overexpression of NR-046683 is closely related to β2-microglobulin. We also found that the overexpression of NR-046683 correlates to chromosomal aberrations, such as del(13q14), gain 1q21, and t(4;14).Conclusion: lncRNA NR_046683 can serve as a novel biomarker for potential drug target and prognostic prediction in MM. | ||
| 546 | |a EN | ||
| 690 | |a lncRNA | ||
| 690 | |a NR_046683 | ||
| 690 | |a multiple myeloma | ||
| 690 | |a prognostic factor | ||
| 690 | |a drug target | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 10 (2019) | |
| 787 | 0 | |n https://www.frontiersin.org/article/10.3389/fphar.2019.00045/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/d1900d1467ce4bbda3d24b43f1fcfceb |z Connect to this object online. |