Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan
Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan extending calorie restriction (CR) decreases glucose-derived metabolic flux through ATP-citrate lyase (ACLY) to reduce cy...
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MDPI AG,
2021-04-01T00:00:00Z.
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