<i>Pseudomonas aeruginosa</i> Infections in Patients with Severe COVID-19 in Intensive Care Units: A Retrospective Study
Patients hospitalized in ICUs with severe COVID-19 are at risk for developing hospital-acquired infections, especially infections caused by <i>Pseudomonas aeruginosa</i>. We aimed to describe the evolution of <i>P. aeruginosa</i> infections in ICUs at CHRU-Nancy (France) in p...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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MDPI AG,
2024-04-01T00:00:00Z.
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| Summary: | Patients hospitalized in ICUs with severe COVID-19 are at risk for developing hospital-acquired infections, especially infections caused by <i>Pseudomonas aeruginosa</i>. We aimed to describe the evolution of <i>P. aeruginosa</i> infections in ICUs at CHRU-Nancy (France) in patients with severe COVID-19 during the three initial waves of COVID-19. The second aims were to analyze <i>P. aeruginosa</i> resistance and to describe the antibiotic treatments. We conducted a retrospective cohort study among adult patients who were hospitalized for acute respiratory distress syndrome due to COVID-19 and who developed a hospital-acquired infection caused by <i>P. aeruginosa</i> during their ICU stay. Among the 51 patients included, most were male (90%) with comorbidities (77%), and the first identification of <i>P. aeruginosa</i> infection occurred after a median ICU stay of 11 days. Several patients acquired infections with MDR (27%) and XDR (8%) <i>P. aeruginosa</i> strains. The agents that strains most commonly exhibited resistance to were penicillin + β-lactamase inhibitors (59%), cephalosporins (42%), monobactams (32%), and carbapenems (27%). Probabilistic antibiotic treatment was prescribed for 49 patients (96%) and was subsequently adapted for 51% of patients after antibiogram and for 33% of patients after noncompliant antibiotic plasma concentration. Hospital-acquired infection is a common and life-threatening complication in critically ill patients. Efforts to minimize the occurrence and improve the treatment of such infections, including infections caused by resistant strains, must be pursued. |
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| Item Description: | 10.3390/antibiotics13050390 2079-6382 |