Population Pharmacokinetics and Initial Dose Optimization of Sirolimus Improving Drug Blood Level for Seizure Control in Pediatric Patients With Tuberous Sclerosis Complex

• Main Authors: Xiao Chen (Author), Dongdong Wang (Author), Lin Zhu (Author), Jinmiao Lu (Author), Yidie Huang (Author), Guangfei Wang (Author), Yiqing Zhu (Author), Qiaofeng Ye (Author), Yi Wang (Author), Hong Xu (Author), Zhiping Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purposes of this study were to explore the population pharmacokinetics and initial dose optimization of sirolimus improving drug blood level for seizure control in pediatric patients with tuberous sclerosis complex (TSC). Eighty pediatric patients diagnosed with TSC-related epilepsy were include...