New In Vitro Coculture Model for Evaluating Intestinal Absorption of Different Lipid Nanocapsules

• Main Authors: Norraseth Kaeokhamloed (Author), Emillie Roger (Author), Jérôme Béjaud (Author), Nolwenn Lautram (Author), Florence Manero (Author), Rodolphe Perrot (Author), Marie Briet (Author), Chadi Abbara (Author), Samuel Legeay (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Standard models used for evaluating the absorption of nanoparticles like Caco-2 ignore the presence of vascular endothelium, which is a part of the intestinal multi-layered barrier structure. Therefore, a coculture between the Caco-2 epithelium and HMEC-1 (Human Microvascular Endothelial Cell type 1...