The Cyclosporine-A Treatment does not have Harmful Effect on the Linear Growth of Pediatric Patients with Steroid-dependent and Steroid-resistant Nephrotic Syndrome

• Main Authors: Sang Soo Lee (Author), Ji Hoon Kim (Author), Chung Ho Kim (Author), Byoung-Soo Cho (Author), Deog Yoon Kim (Author), Il Ki Hong (Author), Jin-Soon Suh (Author)
• Format: Book
• Published: Korean Society of Pediatric Nephrology, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Purpose This study was performed to evaluate the effects of cyclosporine-A (CsA) on linear growth in pediatric patients with steroid-dependent (SDNS) or resistant nephrotic syndrome (SRNS). Methods Thirty-five pediatric patients with SDNS or SRNS undergoing glucocorticoid (GC) and/or CsA treatment were retrospectively reviewed. Seventeen patients were treated with GC alone and 18 were treated with GC and CsA. The cumulative doses of GC and CsA were quantified (mg/kg/day). Linear growth during the follow-up period was defined as the difference in Z-score between the initial and final height according to the follow-up period (Δ height Z score/year). The associations between linear growth and clinical parameters were analyzed. Results The linear growth of patients in the two groups was not significantly different (P =0.262). The Δ height Z score/year did not show a significant correlation with the cumulative doses of CsA, but was negatively correlated with the cumulative dose of GC and positively correlated with the Z score for height at the time of diagnosis. Conclusion In children with SDNS or SRNS undergoing GC therapy, added CsA treatment may not have harmful effects on linear growth.

Item Description

2384-0242
2384-0250
10.3339/jkspn.2016.20.2.45