Regulation of P-Glycoprotein during Oxidative Stress

• Main Authors: Aleksey V. Shchulkin (Author), Yulia V. Abalenikhina (Author), Olga V. Kosmachevskaya (Author), Alexey F. Topunov (Author), Elena N. Yakusheva (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-glycoprotein (Pgp, ABCB1, <i>MDR1</i>) is an efflux transporter protein that removes molecules from the cells (outflow) into the extracellular space. Pgp plays an important role in pharmacokinetics, ensuring the absorption, distribution, and excretion of drugs and its substrates, as we...