Improved Bioavailability of Montelukast through a Novel Oral Mucoadhesive Film in Humans and Mice

• Main Authors: Johanna Michael (Author), Diana Bessa de Sousa (Author), Justin Conway (Author), Erick Gonzalez-Labrada (Author), Rodolphe Obeid (Author), Julia Tevini (Author), Thomas Felder (Author), Birgit Hutter-Paier (Author), Horst Zerbe (Author), Nadine Paiement (Author), Ludwig Aigner (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The leukotriene receptor antagonist Montelukast (MTK) is an approved medication for the treatment of asthma and allergic rhinitis. The existing marketed tablet forms of MTK exhibit inconsistent uptake and bioavailability, which partially explains the presence of a significant proportion of MTK low-...