A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population

Background: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G...

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Main Authors: Zeinab TAVAKKOL AFSHARI (Author), Zahra GHOLIZADEH (Author), Amin Reza NIKPOOR (Author), Jalil TAVAKKOL AFSHARI (Author), Rashin GANJALI (Author), Fatemeh HOMAEI SHANDIZ (Author), Khadijeh JAMIALAHMADI (Author)
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Published: Tehran University of Medical Sciences, 2019-10-01T00:00:00Z.
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LEADER 00000 am a22000003u 4500
001 doaj_d2b75f73a5b04c0e83d7c60c8e53ddfb
042 |a dc 
100 1 0 |a Zeinab TAVAKKOL AFSHARI  |e author 
700 1 0 |a Zahra GHOLIZADEH  |e author 
700 1 0 |a Amin Reza NIKPOOR  |e author 
700 1 0 |a Jalil TAVAKKOL AFSHARI  |e author 
700 1 0 |a Rashin GANJALI  |e author 
700 1 0 |a Fatemeh HOMAEI SHANDIZ  |e author 
700 1 0 |a Khadijeh JAMIALAHMADI  |e author 
245 0 0 |a A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population 
260 |b Tehran University of Medical Sciences,   |c 2019-10-01T00:00:00Z. 
500 |a 10.18502/ijph.v48i10.3493 
500 |a 2251-6085 
500 |a 2251-6093 
520 |a Background: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G4A polymorphism and the risk of breast cancer in a northeastern Iranian population. Methods: This case-control study was performed on 105 patients who admitted in educational hospitals of Mashhad University of Medical Sciences, Iran during 2013-2015, with breast cancer as case group and 120 healthy women as the control group. PCR-CTPP method was used to investigate the relationship between the p73 G4A polymorphism and the risk of breast cancer. Results: There was no significant association between the AA genotype of the p73 G4A polymorphism and breast cancer in case and control groups. Although G allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of breast cancer in this study group. Conclusion: There was no association between G4A p73 polymorphism and the risk of breast cancer in a northeastern Iranian population. 
546 |a EN 
690 |a Tumor protein p73 
690 |a Polymorphism 
690 |a Breast cancer 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Iranian Journal of Public Health, Vol 48, Iss 10 (2019) 
787 0 |n https://ijph.tums.ac.ir/index.php/ijph/article/view/18545 
787 0 |n https://doaj.org/toc/2251-6085 
787 0 |n https://doaj.org/toc/2251-6093 
856 4 1 |u https://doaj.org/article/d2b75f73a5b04c0e83d7c60c8e53ddfb  |z Connect to this object online.