A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population
Background: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G...
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Tehran University of Medical Sciences,
2019-10-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_d2b75f73a5b04c0e83d7c60c8e53ddfb | ||
042 | |a dc | ||
100 | 1 | 0 | |a Zeinab TAVAKKOL AFSHARI |e author |
700 | 1 | 0 | |a Zahra GHOLIZADEH |e author |
700 | 1 | 0 | |a Amin Reza NIKPOOR |e author |
700 | 1 | 0 | |a Jalil TAVAKKOL AFSHARI |e author |
700 | 1 | 0 | |a Rashin GANJALI |e author |
700 | 1 | 0 | |a Fatemeh HOMAEI SHANDIZ |e author |
700 | 1 | 0 | |a Khadijeh JAMIALAHMADI |e author |
245 | 0 | 0 | |a A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population |
260 | |b Tehran University of Medical Sciences, |c 2019-10-01T00:00:00Z. | ||
500 | |a 10.18502/ijph.v48i10.3493 | ||
500 | |a 2251-6085 | ||
500 | |a 2251-6093 | ||
520 | |a Background: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G4A polymorphism and the risk of breast cancer in a northeastern Iranian population. Methods: This case-control study was performed on 105 patients who admitted in educational hospitals of Mashhad University of Medical Sciences, Iran during 2013-2015, with breast cancer as case group and 120 healthy women as the control group. PCR-CTPP method was used to investigate the relationship between the p73 G4A polymorphism and the risk of breast cancer. Results: There was no significant association between the AA genotype of the p73 G4A polymorphism and breast cancer in case and control groups. Although G allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of breast cancer in this study group. Conclusion: There was no association between G4A p73 polymorphism and the risk of breast cancer in a northeastern Iranian population. | ||
546 | |a EN | ||
690 | |a Tumor protein p73 | ||
690 | |a Polymorphism | ||
690 | |a Breast cancer | ||
690 | |a Public aspects of medicine | ||
690 | |a RA1-1270 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Iranian Journal of Public Health, Vol 48, Iss 10 (2019) | |
787 | 0 | |n https://ijph.tums.ac.ir/index.php/ijph/article/view/18545 | |
787 | 0 | |n https://doaj.org/toc/2251-6085 | |
787 | 0 | |n https://doaj.org/toc/2251-6093 | |
856 | 4 | 1 | |u https://doaj.org/article/d2b75f73a5b04c0e83d7c60c8e53ddfb |z Connect to this object online. |