Hyperkalemic effect of drug-drug interaction between esaxerenone and trimethoprim in patients with hypertension: a pilot study

• Main Authors: Toshinori Hirai (Author), Shun Ueda (Author), Toru Ogura (Author), Kan Katayama (Author), Kaoru Dohi (Author), Yuki Kondo (Author), Yuka Sakazaki (Author), Yoichi Ishitsuka (Author), Takuya Iwamoto (Author)
• Format: Book
• Published: BMC, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background We examined whether the pharmacodynamic drug-drug interaction between esaxerenone and trimethoprim enhances the hyperkalemic effect. Methods A retrospective observational study was conducted to identify patients >18 years undertaking esaxerenone alone or esaxerenone plus trime...