K-685, a TRPV1 Antagonist, Blocks PKC-Sensitized TRPV1 Activation and Improves the Inflammatory Pain in a Rat Complete Freund's Adjuvant Model

• Main Authors: Yoshiyuki Sugimoto (Author), Yozo Kojima (Author), Atsushi Inayoshi (Author), Kazuaki Inoue (Author), Hiroko Miura-Kusaka (Author), Kiyotoshi Mori (Author), Osamu Saku (Author), Hiroshi Ishida (Author), Eri Atsumi (Author), Yoshisuke Nakasato (Author), Shiro Shirakura (Author), Shin-ichiro Toki (Author), Katsumi Shinoda (Author), Nobuyuki Suzuki (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable non-selective cation channel that transmits pain signals. TRPV1 is activated by multiple stimuli such as capsaicin, acid, and heat. During inflammation, TRPV1 is reported to be sensitized by protein kinase C (PKC) in dorsal root ga...