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2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis

Periodontitis, a chronic infection by periodontopathic bacteria, induces uncontrolled inflammation, which leads to periodontal tissue destruction. 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-glucoside (THSG), a polyphenol extracted from Polygoni Multiflori, reportedly has anti-inflammatory propertie...

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Main Authors: Yu-Tang Chin (Author), Meng-Ti Hsieh (Author), Chi-Yu Lin (Author), Po-Jan Kuo (Author), Yu-Chen S. H. Yang (Author), Ya-Jung Shih (Author), Hsuan-Yu Lai (Author), Guei-Yun Cheng (Author), Heng-Yuan Tang (Author), Chen-Chen Lee (Author), Sheng-Yang Lee (Author), Ching-Chiung Wang (Author), Hung-Yun Lin (Author), Earl Fu (Author), Jacqueline Whang-Peng (Author), Leroy F. Liu (Author)
Format: Book
Published: Hindawi Limited, 2016-01-01T00:00:00Z.
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Summary:Periodontitis, a chronic infection by periodontopathic bacteria, induces uncontrolled inflammation, which leads to periodontal tissue destruction. 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-glucoside (THSG), a polyphenol extracted from Polygoni Multiflori, reportedly has anti-inflammatory properties. In this study, we investigated the mechanisms of THSG on the Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. Human gingival fibroblast cells were treated with lipopolysaccharide (LPS) extracted from P. gingivalis in the presence of resveratrol or THSG to analyze the expression of TNF-α, IL-1β, and IL-6 genes. Increased AMP-activated protein kinase (AMPK) activation and SirT1 expression were induced by THSG. Treatment of THSG decreased the expression of LPS-induced inflammatory cytokines, enhanced AMPK activation, and increased the expression of SirT1. In addition, it suppressed the activation of NF-κB when cells were stimulated with P. gingivalis LPS. The anti-inflammatory effect of THSG and P. Multiflori crude extracts was reproduced in ligature-induced periodontitis animal modeling. In conclusion, THSG inhibited the inflammatory responses of P. gingivalis-stimulated human gingival fibroblasts and ameliorated ligature-induced periodontitis in animal model.
Item Description:0962-9351
1466-1861
10.1155/2016/6953459

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