2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis
Periodontitis, a chronic infection by periodontopathic bacteria, induces uncontrolled inflammation, which leads to periodontal tissue destruction. 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-glucoside (THSG), a polyphenol extracted from Polygoni Multiflori, reportedly has anti-inflammatory propertie...
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Hindawi Limited,
2016-01-01T00:00:00Z.
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| 001 | doaj_d354c8c68ebd46a5a566a76d3a5d78cf | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yu-Tang Chin |e author |
| 700 | 1 | 0 | |a Meng-Ti Hsieh |e author |
| 700 | 1 | 0 | |a Chi-Yu Lin |e author |
| 700 | 1 | 0 | |a Po-Jan Kuo |e author |
| 700 | 1 | 0 | |a Yu-Chen S. H. Yang |e author |
| 700 | 1 | 0 | |a Ya-Jung Shih |e author |
| 700 | 1 | 0 | |a Hsuan-Yu Lai |e author |
| 700 | 1 | 0 | |a Guei-Yun Cheng |e author |
| 700 | 1 | 0 | |a Heng-Yuan Tang |e author |
| 700 | 1 | 0 | |a Chen-Chen Lee |e author |
| 700 | 1 | 0 | |a Sheng-Yang Lee |e author |
| 700 | 1 | 0 | |a Ching-Chiung Wang |e author |
| 700 | 1 | 0 | |a Hung-Yun Lin |e author |
| 700 | 1 | 0 | |a Earl Fu |e author |
| 700 | 1 | 0 | |a Jacqueline Whang-Peng |e author |
| 700 | 1 | 0 | |a Leroy F. Liu |e author |
| 245 | 0 | 0 | |a 2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis |
| 260 | |b Hindawi Limited, |c 2016-01-01T00:00:00Z. | ||
| 500 | |a 0962-9351 | ||
| 500 | |a 1466-1861 | ||
| 500 | |a 10.1155/2016/6953459 | ||
| 520 | |a Periodontitis, a chronic infection by periodontopathic bacteria, induces uncontrolled inflammation, which leads to periodontal tissue destruction. 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-glucoside (THSG), a polyphenol extracted from Polygoni Multiflori, reportedly has anti-inflammatory properties. In this study, we investigated the mechanisms of THSG on the Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. Human gingival fibroblast cells were treated with lipopolysaccharide (LPS) extracted from P. gingivalis in the presence of resveratrol or THSG to analyze the expression of TNF-α, IL-1β, and IL-6 genes. Increased AMP-activated protein kinase (AMPK) activation and SirT1 expression were induced by THSG. Treatment of THSG decreased the expression of LPS-induced inflammatory cytokines, enhanced AMPK activation, and increased the expression of SirT1. In addition, it suppressed the activation of NF-κB when cells were stimulated with P. gingivalis LPS. The anti-inflammatory effect of THSG and P. Multiflori crude extracts was reproduced in ligature-induced periodontitis animal modeling. In conclusion, THSG inhibited the inflammatory responses of P. gingivalis-stimulated human gingival fibroblasts and ameliorated ligature-induced periodontitis in animal model. | ||
| 546 | |a EN | ||
| 690 | |a Pathology | ||
| 690 | |a RB1-214 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Mediators of Inflammation, Vol 2016 (2016) | |
| 787 | 0 | |n http://dx.doi.org/10.1155/2016/6953459 | |
| 787 | 0 | |n https://doaj.org/toc/0962-9351 | |
| 787 | 0 | |n https://doaj.org/toc/1466-1861 | |
| 856 | 4 | 1 | |u https://doaj.org/article/d354c8c68ebd46a5a566a76d3a5d78cf |z Connect to this object online. |