Pyroptosis and necroptosis inhibitor necrosulfonamide ameliorates lipopolysaccharide-induced inflammatory hyperalgesia in mice

• Main Authors: Beyza Ozgen (Author), Sefika Pinar Senol (Author), Dilsah Ezgi Yilmaz (Author), Meryem Temiz-Resitoglu (Author), Omer Bahceli (Author), Bahar Tunctan (Author)
• Format: Book
• Published: Pensoft Publishers, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: This study aimed to investigate the effect of the gasdermin D (GSDMD) and mixed lineage kinase domain-like pseudokinase (MLKL) inhibitor, necrosulfonamide (NSA), on lipopolysaccharide (LPS)-induced hyperalgesia in mice. Methods: Reaction time to a thermal stimulus within 30 seconds was m...