A Potent Apoptosis-Inducing Activity of a Sesquiterpene Lactone, Arucanolide, in HL60 Cells: a Crucial Role of Apoptosis-Inducing Factor

• Main Authors: Yoshihito Nakagawa (Author), Munekazu Iinuma (Author), Nobuyasu Matsuura (Author), Kong Yi (Author), Makoto Naoi (Author), Toshihiro Nakayama (Author), Yoshinori Nozawa (Author), Yukihiro Akao (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Six main sesquiterpene lactones (germacranolides) from Calea urticifolia were evaluated for in vitro cytotoxicity against human tumor cell lines HL60 and SW480 cells. Among them, arucanolide and parthenolide displayed marked cytotoxicity against both cell lines. Arucanolide exhibited a low IC50 in H...