Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions

• Main Authors: Simeon Rüdesheim (Author), Jan-Georg Wojtyniak (Author), Dominik Selzer (Author), Nina Hanke (Author), Felix Mahfoud (Author), Matthias Schwab (Author), Thorsten Lehr (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The beta-blocker metoprolol (the sixth most commonly prescribed drug in the USA in 2017) is subject to considerable drug-gene interaction (DGI) effects caused by genetic variations of the <i>CYP2D6</i> gene. CYP2D6 poor metabolizers (5.7% of US population) show approximately five-fold hi...