Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles

Retinoblastoma (Rb) represents 3% of all childhood malignancies and seriously endangers children's lives and quality of life. Early diagnosis and treatment can save children's vision as much as possible. Multifunctional nanoparticles have become a research hotspot in recent years and are e...

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Main Authors: Hongmi Zou (Author), Meng Li (Author), Xing Li (Author), Wendi Zheng (Author), Hongyu Kuang (Author), Menglei Wang (Author), Wenli Zhang (Author), Haitao Ran (Author), Huafeng Ma (Author), Xiyuan Zhou (Author)
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Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Hongmi Zou  |e author 
700 1 0 |a Meng Li  |e author 
700 1 0 |a Xing Li  |e author 
700 1 0 |a Wendi Zheng  |e author 
700 1 0 |a Hongyu Kuang  |e author 
700 1 0 |a Menglei Wang  |e author 
700 1 0 |a Wenli Zhang  |e author 
700 1 0 |a Haitao Ran  |e author 
700 1 0 |a Huafeng Ma  |e author 
700 1 0 |a Xiyuan Zhou  |e author 
245 0 0 |a Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles 
260 |b Taylor & Francis Group,   |c 2022-12-01T00:00:00Z. 
500 |a 10.1080/10717544.2022.2081379 
500 |a 1521-0464 
500 |a 1071-7544 
520 |a Retinoblastoma (Rb) represents 3% of all childhood malignancies and seriously endangers children's lives and quality of life. Early diagnosis and treatment can save children's vision as much as possible. Multifunctional nanoparticles have become a research hotspot in recent years and are expected to realize the integration of early diagnosis and early treatment. Therefore, we report a nanoparticle with dual-mode imaging, photothermal therapy, and immune activation: carbonized MOF nanoparticles (CM NPs) loaded with the immune polypeptide tuftsin (CMT NPs). The dual-mode imaging ability, antitumor effect, and macrophage immunity activation ability of these nanoparticles combined with laser irradiation were studied. The biosafety of CMT NPs was detected. The multifunctional magnetic nanoparticles enhanced photoacoustic (PA) and magnetic resonance (MR) imaging in vivo and in vitro, facilitating diagnosis and efficacy evaluation. The combined effect of CMT NPs and laser irradiation was recorded and verified. Through the accumulation of magnetic field nanoparticles in tumors, the photothermal conversion of nanoparticles under laser irradiation led directly to tumor apoptosis/necrosis, and the release of tuftsin induced macrophage M1-type activation, resulting in antitumor immune effects. Enhanced PA/MR imaging CMT NPs have great potential in dual-mode image-guided laser/immune cotherapy. The nanoparticles have high biosafety and have potential in cancer treatment. 
546 |a EN 
690 |a Nanoparticles 
690 |a combination therapy 
690 |a dual-mode imaging 
690 |a target 
690 |a retinoblastoma 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Drug Delivery, Vol 29, Iss 1, Pp 1785-1799 (2022) 
787 0 |n https://www.tandfonline.com/doi/10.1080/10717544.2022.2081379 
787 0 |n https://doaj.org/toc/1071-7544 
787 0 |n https://doaj.org/toc/1521-0464 
856 4 1 |u https://doaj.org/article/d3ca17d75dce42e4a1642a99e155aad3  |z Connect to this object online.