Adenosine deaminase enzyme activity is increased and negatively correlates with catalase, superoxide dismutase and glutathione peroxidase in patients with Behçet's disease: original contributions/clinical and laboratory investigations

• Main Authors: Kuddusi Erkiliç (Author), Cem Evereklioglu (Author), Mustafa Çekmen (Author), Abdullah Özkiris (Author), Fuat Duygulu (Author), Hakki Dogan (Author)
• Format: Book
• Published: Hindawi Limited, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Aim: Behçet's disease (BD) is an inflammatory vasculitis with immunologic, endothelial and neutrophil alterations. Adenosine deaminase (AD) is a marker of T-cell activation and is related to the production of reactive oxygen species by neutrophils with the production of NO•, O2•-, H2O2 and OH•. We reported increased tumour necrosis factor-α, soluble interleukin-2 receptor, interleukin-6, interleukin-8 and NO• in active BD. As there is a relation between cytokines, T cells and oxidative stress in inflammatory diseases, this study further evaluated: (1) plasma AD activity and its correlation with acute phase reactants; (2) thiobarbituric acid-reactive substances (TBARS) as an indicator for lipid peroxidation; and (3) antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and catalase in patients with BD. The effect of disease activity and correlations between the measured parameters were explored.

Item Description

0962-9351
1466-1861
10.1080/0962935031000097754