The Novel Aminomethylcycline Omadacycline Has High Specificity for the Primary Tetracycline-Binding Site on the Bacterial Ribosome

• Main Authors: Corina G. Heidrich (Author), Sanya Mitova (Author), Andreas Schedlbauer (Author), Sean R. Connell (Author), Paola Fucini (Author), Judith N. Steenbergen (Author), Christian Berens (Author)
• Format: Book
• Published: MDPI AG, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Omadacycline is an aminomethylcycline antibiotic with potent activity against many Gram-positive and Gram-negative pathogens, including strains carrying the major efflux and ribosome protection resistance determinants. This makes it a promising candidate for therapy of severe infectious diseases. Om...