Tissue Engineering of Cartilage; Can Cannabinoids Help?

This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid system has potential in mesenchymal stem cell based tissue-engineered cartilage repair strategies. The review discusses the potential of cannabinoids to protect agains...

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Bibliographic Details
Main Authors: Aoife Gowran (Author), Katey McKayed (Author), Manoj Kanichai (Author), Cillian White (Author), Veronica Campbell (Author), Nissrin Hammadi (Author)
Format: Book
Published: MDPI AG, 2010-09-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Aoife Gowran  |e author 
700 1 0 |a Katey McKayed  |e author 
700 1 0 |a Manoj Kanichai  |e author 
700 1 0 |a Cillian White  |e author 
700 1 0 |a Veronica Campbell  |e author 
700 1 0 |a Nissrin Hammadi  |e author 
245 0 0 |a Tissue Engineering of Cartilage; Can Cannabinoids Help? 
260 |b MDPI AG,   |c 2010-09-01T00:00:00Z. 
500 |a 10.3390/ph3092970 
500 |a 1424-8247 
520 |a This review discusses the role of the cannabinoid system in cartilage tissue and endeavors to establish if targeting the cannabinoid system has potential in mesenchymal stem cell based tissue-engineered cartilage repair strategies. The review discusses the potential of cannabinoids to protect against the degradation of cartilage in inflamed arthritic joints and the influence of cannabinoids on the chondrocyte precursors, mesenchymal stem cells (MSCs). We provide experimental evidence to show that activation of the cannabinoid system enhances the survival, migration and chondrogenic differentiation of MSCs, which are three major tenets behind the success of a cell-based tissue-engineered cartilage repair strategy. These findings highlight the potential for cannabinoids to provide a dual function by acting as anti-inflammatory agents as well as regulators of MSC biology in order to enhance tissue engineering strategies aimed at cartilage repair. 
546 |a EN 
690 |a phytocannabinoids 
690 |a cannabinoid receptors 
690 |a mesenchymal stem cells 
690 |a osteoarthritis 
690 |a cartilage 
690 |a Medicine 
690 |a R 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Pharmaceuticals, Vol 3, Iss 9, Pp 2970-2985 (2010) 
787 0 |n http://www.mdpi.com/1424-8247/3/9/2970/ 
787 0 |n https://doaj.org/toc/1424-8247 
856 4 1 |u https://doaj.org/article/d459b9a579ce486f88f2ece19b48adf3  |z Connect to this object online.