Association of UGT1A1*6, UGT1A1*28, or ABCC2 c.3972C>T genetic polymorphisms with irinotecan‐induced toxicity in Asian cancer patients: Meta‐analysis

• Main Authors: Chalirmporn Atasilp (Author), Mohitosh Biswas (Author), Pimonpan Jinda (Author), Nutthan Nuntharadthanaphong (Author), Jiratha Rachanakul (Author), Yaowaluck Hongkaew (Author), Natchaya Vanwong (Author), Surasak Saokaew (Author), Chonlaphat Sukasem (Author)
• Format: Book
• Published: Wiley, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Effects of UGT1A1*6 and UGT1A1*28 genetic polymorphisms on irinotecan‐induced severe toxicities in Asian cancer patients are inconclusive. Also, ABCC2 c.3972C>T may affect toxicity of irinotecan. The aim was to assess the aggregated risk of neutropenia or diarrhea in Asian cancer patient...