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Obstacles in combating multidrug resistant tuberculosis in pediatric patients: a scope review

Abstract Objectives: to identify the scientific evidence on excessively resistant and multidrug resistant tuberculosis in pediatric patients. Methods: this is a scope review of the literature, with a guiding question: "What is the scientific evidence on multidrug-resistant tuberculosis (MDR-TB)...

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Main Authors: Letícia Baltar Sobreira (Author), Paula de Souza Silva Freitas (Author), Luciana de Cassia Nunes Nascimento (Author), Anne Caroline Barbosa Cerqueira Vieira (Author), Carolina Maia Martins Sales (Author), Alicia de Oliveira Pacheco (Author), Lucas Dalvi Armond Rezende (Author)
Format: Book
Published: Instituto Materno Infantil de Pernambuco, 2024-01-01T00:00:00Z.
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Summary:Abstract Objectives: to identify the scientific evidence on excessively resistant and multidrug resistant tuberculosis in pediatric patients. Methods: this is a scope review of the literature, with a guiding question: "What is the scientific evidence on multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis in pediatric patients?". The research used the descriptors: "extensively drug-resistant tuberculosis" OR "multidrug-resistant tuberculosis" AND "pediatrics". The research was carried out in a double-blind manner in the following databases of the Medical Literature Analysis and Retrieval System Online, Regional Office for the Western Pacific's Institutional Repository for Information Sharing, Embase/Elsevier and International Clinical Trials Registry Platform, with a temporal cut-off from 2011 to 2021, sending a final synthesized sample of 18 articles, which evaluated the methodological content through the level of evidence. Results: the results show the lack of research with a high level of evidence related to MDR-TB in children, the lack of adequate dosage of second-line drugs for the pediatric population and the importance of drug sensitivity testing for the cases of treatment Conclusions: it was identified that the obstacles to MDR-TB treatment were concentrated in the lack of detailed protocols, safe drug dosages with a low side effect, and mainly in the social health determinants and disease process involving MDR-TB.
Item Description:1806-9304
10.1590/1806-9304202400000082-en

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