Preparation of Poly (N-Cephalexin Amic Acids) as Drug Polymers

• Main Authors: Firyal M.A. AL-Salami (Author), Khudheyer G.K (Author), Abbas N.M. AL-Sharify (Author)
• Format: Book
• Published: College of Pharmacy / Mustansiriyah University, 2012-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.32947/ajps.v12i2.230; 1815-0993; 2959-183X
• Keywords: Cephalexine; Amic Acids; Drug Polymers; Pharmacy and materia medica; RS1-441
• Source: Al-Mustansiriyah Journal of Pharmaceutical Sciences, Vol 12, Iss 2 (2012)

In this work new monomers have been prepared such as N-Cephalexin maleamic acid M1 and N-Cephalexin citriconamic acid M2 , from reaction of Cephalexine with maleic anhydride and citraconic anhydride at room temperature using dioxane as a solvent. The new prepared monomers M1and M2 were polymerized free radically with AIBN as initiator to their corresponding poly amic acids P1 and P2. Which were converted to their sodium salt polymers P3 and P4 to enhance their solubility in water. The physical and chemical properties were studied; the prepared monomers and polymers were characterized by FTIR, 1H-NMR and UV. Spectroscopy, the intrinsic viscosity was measured by Ostwald viscometer at 30 0C with DMF as a solvent; the drug release rate was studied. Experimental results showed that the hydrolysis of Cephalexin in alkaline medium was higher than acidic medium. The softening point of the prepared P1 drug polymer was 130.23-138.350C with-190.17mJ as used in softing point,and softening point of the prepared P2 was 207-2200C