Synthesis and Study of Many New Chalcone Derivatives

• Main Authors: Natiq G. Ahmad (Author), Murtatha H. Ali (Author)
• Format: Book
• Published: College of Education for Pure Sciences, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

This study include the synthesis of the compound 1-(1H-benzo[d]imidazol-2-yl)ethanol [1], from the reaction of ortho pheneylene diamine with lactic acid and then oxidized using potassium dichromate to give1-(1H-benzo[d]imidazol-2-yl) ethanone [2]. Reaction of this compound with different substituted benzaldehydes or 1-(1H-benzo[d]imidazol-2-yl)ethanone, to obtain α, β-unsaturated carbonyl compounds (chalcones) [3-11]. These chalcones have been used in preparing number of heterocyclic compounds through reaction with the hydrogen peroxide to get the oxiran compounds (three membered rings) [12-20], hydroxyl amine hydrochloride to prepare the isooxazoline compounds(five membered rings) [21-29], 3-nitrobenzohydrazide to prepare the pyrazoline compounds(five membered rings)[30-38], thiosemicarbazide hydrochloride to prepare the pyrazoline compounds(five membered rings) [39-47], semicarbazide to prepare the pyrazoline compounds(five membered rings) [48-56], guanidine nitrate to prepare the pyrimidine compounds(six membered rings) [57-65], ortho pheneylenediamine to prepare the benzodiazepine compounds (seven membered rings) [66-74], ortho aminophenol to prepare the benzoxazepine compounds(seven membered rings) [75-83].<br /> The synthesized compounds were identified, using chemical, physical and spectral methods (melting points, color change, infrared spectra, ultraviolet spectra, nuclear magnetic resonance spectra and many theoretical studies).

Item Description

1812-125X
2664-2530
10.33899/edusj.2018.159283