Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission

• Main Authors: Maarten Ooms (Author), Sofie Celen (Author), Ronald De Hoogt (Author), Ilse Lenaerts (Author), Johnny Liebregts (Author), Greet Vanhoof (Author), Xavier Langlois (Author), Andrey Postnov (Author), Michel Koole (Author), Alfons Verbruggen (Author), Koen Van Laere (Author), Guy Bormans (Author)
• Format: Book
• Published: SpringerOpen, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Phosphodiesterase 10A (PDE10A) is an important regulator of nigrostriatal dopamine (DA) neurotransmission. However, little is known on the effect of alterations in DA neurotransmission on PDE10A availability. Here, we used [18F]JNJ42259152 PET to measure changes in PDE10A availab...