Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens

• मुख्य लेखकों: Kyo Won Lee (लेखक), Tae Hwan Kim (लेखक), Jong Bong Lee (लेखक), Kyeong Sik Kim (लेखक), Jae Berm Park (लेखक), Pavel Gershkovich (लेखक), Sun Dong Yoo (लेखक), Soyoung Shin (लेखक), Beom Soo Shin (लेखक), Sung Joo Kim (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2019-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Tacrolimus is one of the most commonly used immunosuppressive agents in animal models of transplantation. However, in these models, oral administration is often problematic due to the lowered compliance associated with highly invasive surgery and due to malabsorption in the intestinal tract. Therefo...