Nitric oxide from IFNγ-primed macrophages modulates the antimicrobial activity of β-lactams against the intracellular pathogens Burkholderia pseudomallei and Nontyphoidal Salmonella.

• Asıl Yazarlar: Jessica Jones-Carson (Yazar), Adrienne E Zweifel (Yazar), Timothy Tapscott (Yazar), Chad Austin (Yazar), Joseph M Brown (Yazar), Kenneth L Jones (Yazar), Martin I Voskuil (Yazar), Andrés Vázquez-Torres (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2014-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Our investigations show that nonlethal concentrations of nitric oxide (NO) abrogate the antibiotic activity of β-lactam antibiotics against Burkholderia pseudomallei, Escherichia coli and nontyphoidal Salmonella enterica serovar Typhimurium. NO protects B. pseudomallei already exposed to β-lactams,...