Traditional uses, phytochemistry, pharmacology, quality control and clinical studies of Cimicifugae Rhizoma: a comprehensive review

Abstract Cimicifugae Rhizoma, generally known as "Sheng Ma" in China, has great medicinal and dietary values. Cimicifugae Rhizoma is the dried rhizome of Cimicifuga foetida L., Cimicifuga dahurica (Turcz.) Maxim. and Cimicifuga heracleifolia Kom., which has been used to treat wind-heat hea...

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Main Authors: Qianqian Zhang (Author), Wei Wei (Author), Xingyue Jin (Author), Jin Lu (Author), Shujing Chen (Author), Omachi Daniel Ogaji (Author), Shaoxia Wang (Author), Kunze Du (Author), Yanxu Chang (Author), Jin Li (Author)
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יצא לאור: BMC, 2024-05-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Qianqian Zhang  |e author 
700 1 0 |a Wei Wei  |e author 
700 1 0 |a Xingyue Jin  |e author 
700 1 0 |a Jin Lu  |e author 
700 1 0 |a Shujing Chen  |e author 
700 1 0 |a Omachi Daniel Ogaji  |e author 
700 1 0 |a Shaoxia Wang  |e author 
700 1 0 |a Kunze Du  |e author 
700 1 0 |a Yanxu Chang  |e author 
700 1 0 |a Jin Li  |e author 
245 0 0 |a Traditional uses, phytochemistry, pharmacology, quality control and clinical studies of Cimicifugae Rhizoma: a comprehensive review 
260 |b BMC,   |c 2024-05-01T00:00:00Z. 
500 |a 10.1186/s13020-024-00937-7 
500 |a 1749-8546 
520 |a Abstract Cimicifugae Rhizoma, generally known as "Sheng Ma" in China, has great medicinal and dietary values. Cimicifugae Rhizoma is the dried rhizome of Cimicifuga foetida L., Cimicifuga dahurica (Turcz.) Maxim. and Cimicifuga heracleifolia Kom., which has been used to treat wind-heat headache, tooth pain, aphtha, sore throat, prolapse of anus and uterine prolapse in traditional Chinese medicine. This review systematically presents the traditional uses, phytochemistry, pharmacology, clinical studies, quality control and toxicity of Cimicifugae Rhizoma in order to propose scientific evidence for its rational utilization and product development. Herein, 348 compounds isolated or identified from the herb are summarized in this review, mainly including triterpenoid saponins, phenylpropanoids, chromones, alkaloids, terpenoids and flavonoids. The crude extracts and its constituents had various pharmacological properties such as anti-inflammatory, antitumor, antiviral, antioxidant, neuroprotective, anti-osteoporosis and relieving menopausal symptoms. The recent research progress of Cimicifugae Rhizoma in ethnopharmacology, phytochemistry and pharmacological effects demonstrates the effectiveness of its utilization and supplies valuable guidance for further research. This review will provide a basis for the future development and utilization of Cimicifugae Rhizoma. 
546 |a EN 
690 |a Cimicifugae Rhizoma 
690 |a Phytochemistry 
690 |a Triterpenoid saponins 
690 |a Pharmacology 
690 |a Quality control 
690 |a Other systems of medicine 
690 |a RZ201-999 
655 7 |a article  |2 local 
786 0 |n Chinese Medicine, Vol 19, Iss 1, Pp 1-18 (2024) 
787 0 |n https://doi.org/10.1186/s13020-024-00937-7 
787 0 |n https://doaj.org/toc/1749-8546 
856 4 1 |u https://doaj.org/article/d54d8ca629f44f4fbaf190c0b1b4b24f  |z Connect to this object online.