Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.

• Hauptverfasser: Suélen Fernandes Silva (Verfasst von), Angélica Hollunder Klippel (Verfasst von), Priscila Zonzini Ramos (Verfasst von), André da Silva Santiago (Verfasst von), Sandro Roberto Valentini (Verfasst von), Mario Henrique Bengtson (Verfasst von), Katlin Brauer Massirer (Verfasst von), Elizabeth Bilsland (Verfasst von), Rafael Miguez Couñago (Verfasst von), Cleslei Fernando Zanelli (Verfasst von)
• Format: Buch
• Veröffentlicht: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• Schlagworte: article
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Deoxyhypusine synthase (DHS) catalyzes the first step of the post-translational modification of eukaryotic translation factor 5A (eIF5A), which is the only known protein containing the amino acid hypusine. Both proteins are essential for eukaryotic cell viability, and DHS has been suggested as a goo...