Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.

• Κύριοι συγγραφείς: Suélen Fernandes Silva (Συγγραφέας), Angélica Hollunder Klippel (Συγγραφέας), Priscila Zonzini Ramos (Συγγραφέας), André da Silva Santiago (Συγγραφέας), Sandro Roberto Valentini (Συγγραφέας), Mario Henrique Bengtson (Συγγραφέας), Katlin Brauer Massirer (Συγγραφέας), Elizabeth Bilsland (Συγγραφέας), Rafael Miguez Couñago (Συγγραφέας), Cleslei Fernando Zanelli (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Deoxyhypusine synthase (DHS) catalyzes the first step of the post-translational modification of eukaryotic translation factor 5A (eIF5A), which is the only known protein containing the amino acid hypusine. Both proteins are essential for eukaryotic cell viability, and DHS has been suggested as a goo...